Peptides and IVF: Kisspeptin, NAD+, and What the Fertility Research Actually Shows

If you’re going through IVF or preparing for a fertility treatment cycle, you’re probably researching everything that could improve your chances. Peptides like kisspeptin, BPC-157, and NAD+ have mechanisms that theoretically relate to reproductive function — but the evidence for using them alongside IVF is almost entirely preclinical. Here’s what the research actually shows and what it doesn’t.

Kisspeptin: The Fertility Peptide Under Active Investigation

Kisspeptin-10 is the most directly fertility-relevant peptide. It is the master regulator of the HPG axis — the hormonal cascade that controls ovulation. Kisspeptin triggers GnRH release from the hypothalamus, which triggers LH and FSH from the pituitary, which drives follicle development and ovulation.

Clinical research is actively exploring kisspeptin as a trigger for final oocyte maturation in IVF, potentially as an alternative to hCG triggers. Published human studies at Imperial College London have shown that kisspeptin-54 can trigger egg maturation with a lower risk of ovarian hyperstimulation syndrome (OHSS) compared to hCG. This is particularly relevant for women with PCOS, who are at higher OHSS risk.

Other Peptides With Theoretical Fertility Relevance

NAD+ — Egg Quality

Oocyte quality declines with age partly due to mitochondrial dysfunction. NAD+ supports mitochondrial function, and animal studies have shown that NAD+ precursors (NMN) can improve oocyte quality in aged mice. Human data is limited but the biological rationale is sound. NAD+ supplementation is being explored in the fertility space, though primarily through oral precursors (NMN/NR) rather than injectable NAD+.

GHK-Cu — Endometrial Receptivity (Theoretical)

GHK-Cu promotes tissue remodeling and blood vessel formation. Endometrial receptivity depends on proper vascularization and tissue development. The connection is theoretical — no studies have directly tested GHK-Cu for endometrial preparation.

What to Discuss With Your RE

If you’re considering peptides alongside IVF:

• Disclose everything to your reproductive endocrinologist. Peptides can affect hormonal signaling.
• Timing matters: Some peptides should be discontinued before an IVF cycle to avoid interference with controlled stimulation protocols.
• Focus on proven interventions first: CoQ10, DHEA (if indicated), vitamin D, folate, and lifestyle optimization have more clinical support than research peptides for fertility.

Frequently Asked Questions

Related Articles