A tetrapeptide that activates telomerase — the enzyme that maintains telomere length, the "biological clock" of cellular aging. Backed by 35+ years of research from the St. Petersburg Institute of Bioregulation and Gerontology.
Epitalon (epithalamin, Ala-Glu-Asp-Gly) is a synthetic version of the naturally occurring pineal gland peptide epithalamin. It activates telomerase, the enzyme responsible for maintaining telomere length — the protective caps on chromosomes that shorten with each cell division. Telomere shortening is a primary hallmark of cellular aging. Epitalon also influences melatonin production and circadian rhythm regulation.
Telomere attrition accelerates during perimenopause and menopause, contributing to visible aging, reduced cellular repair capacity, and increased disease susceptibility. Epitalon is one of the few compounds with evidence of telomerase reactivation. Its effects on melatonin production are also relevant — perimenopause disrupts melatonin synthesis, contributing to the sleep difficulties that 60% of menopausal women experience.
Epitalon is generally well-tolerated in available studies. Side effects are minimal and may include mild injection site reactions. As a naturally occurring peptide analog, systemic toxicity appears low. Long-term human safety data from controlled trials is limited.
Epitalon activates telomerase, which maintains telomere length — a key biomarker of cellular aging. Animal studies show lifespan extension, but "reversing aging" in humans has not been demonstrated. It may slow certain aspects of cellular aging.
Epitalon is most commonly administered via subcutaneous injection in cycles (typically 10-20 days). Some practitioners use it 1-2 times per year as a maintenance protocol.
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Medical Disclaimer: This profile is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide therapy.
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